Multiple linear regression attempts to model the relationship between two or more explanatory variables and a response variable by fitting a linear equation to observed data. Every value of the independent variable *x* is associated with a value of the dependent variable *y*. The population regression line for *p* explanatory variables *x*_{1}, *x*_{2}, … , *x*_{p} is defined to be _{y} = _{0} + _{1}*x*_{1} + _{2}*x*_{2} + … + _{p}*x*_{p}. This line describes how the mean response _{y} changes with the explanatory variables. The observed values for *y* vary about their means _{y} and are assumed to have the same standard deviation . The fitted values *b _{0}*,

*b*, …,

_{1}*b*estimate the parameters

_{p}_{0},

_{1}, …,

_{p}of the population regression line.

Since the observed values for *y* vary about their means _{y}, the multiple regression model includes a term for this variation. In words, the model is expressed as DATA = FIT + RESIDUAL, where the “FIT” term represents the expression _{0} + _{1}*x*_{1} + _{2}*x*_{2} + … _{p}*x*_{p}. The “RESIDUAL” term represents the deviations of the observed values *y* from their means _{y}, which are normally distributed with mean 0 and variance . The notation for the model deviations is .

**Formally, the model for multiple linear regression, given n observations, is
y_{i} = _{0} + _{1}x_{i1} + _{2}x_{i2} + … _{p}x_{ip} + _{i} for i = 1,2, … n.**

In the least-squares model, the best-fitting line for the observed data is calculated by minimizing the sum of the squares of the vertical deviations from each data point to the line (if a point lies on the fitted line exactly, then its vertical deviation is 0). Because the deviations are first squared, then summed, there are no cancellations between positive and negative values. The least-squares estimates *b _{0}*,

*b*, …

_{1}*b*are usually computed by statistical software.

_{p}The values fit by the equation *b _{0}* +

*b*+ … +

_{1}x_{i1}*b*are denoted

_{p}x_{ip}*, and the residuals*

_{i}*e*are equal to

_{i}*y*, the difference between the observed and fitted values. The sum of the residuals is equal to zero.

_{i}–_{i}The variance ² may be estimated by ** s² = **, also known as the mean-squared error (or MSE).

The estimate of the standard error

*s*is the square root of the MSE.

### Example

The dataset “Healthy Breakfast” contains, among other variables, the *Consumer Reports* ratings of 77 cereals and the number of grams of sugar contained in each serving. (*Data source: Free publication available in many grocery stores. Dataset available through the Statlib Data and Story Library (DASL).*)

A simple linear regression model considering “Sugars” as the explanatory variable and “Rating” as the response variable produced the regression line

Rating = 59.3 – 2.40 Sugars, with the square of the correlation *r*² = 0.577 (see Inference in Linear Regression for more details on this regression).

The “Healthy Breakfast” dataset includes several other variables, including grams of fat per serving and grams of dietary fiber per serving. Is the model significantly improved when these variables are included?

Suppose we are first interested in adding the “Fat” variable. The correlation between “Fat” and “Rating” is equal to -0.409, while the correlation between “Sugars” and “Fat” is equal to 0.271. Since “Fat” and “Sugar” are not highly correlated, the addition of the “Fat” variable may significantly improve the model.

The MINITAB “Regress” command produced the following results:

Regression Analysis The regression equation is Rating = 61.1 - 3.07 Fat - 2.21 Sugars

After fitting the regression line, it is important to investigate the residuals to determine whether or not they appear to fit the assumption of a normal distribution. A normal quantile plot of the standardized residuals *y – * is shown to the left. Despite two large values which may be outliers in the data, the residuals do not seem to deviate from a random sample from a normal distribution in any systematic manner.

The MINITAB output provides a great deal of information. Under the equation for the regression line, the output provides the least-squares estimates for each parameter, listed in the “Coef” column next to the variable to which it corresponds. The calculated standard deviations are provided in the second column.

Predictor Coef StDev T P Constant 61.089 1.953 31.28 0.000 Fat -3.066 1.036 -2.96 0.004 Sugars -2.2128 0.2347 -9.43 0.000 S = 8.755 R-Sq = 62.2% R-Sq(adj) = 61.2%

### Significance Tests

The third column “T” of the MINITAB “REGRESS” output provides test statistics. As in linear regression, one wishes to test the significance of the parameters included. For any of the variables *x*_{j} included in a multiple regression model, the null hypothesis states that the coefficient _{j} is equal to 0. The alternative hypothesis may be one-sided or two-sided, stating that _{j} is either less than 0, greater than 0, or simply not equal to 0.

**The test statistic t is equal to **** b_{j}/s_{bj}**, the parameter estimate divided by its standard deviation. This value follows a

*t(n-p-1)*distribution when

*p*variables are included in the model.

In the example above, the parameter estimate for the “Fat” variable is -3.066 with standard deviation 1.036 The test statistic is t = -3.066/1.036 = -2.96, provided in the “T” column of the MINITAB output. For a two-sided test, the probability of interest is 2*P(T>|-2.96|)* for the *t(77-2-1)* = *t(74)* distribution, which is about 0.004. The “P” column of the MINITAB output provides the *P*-value associated with the two-sided test. Since the *P*-values for both “Fat” and “Sugar” are highly significant, both variables may be included in the model.

### Condidence Intervals for Regression Parameters

**A level C confidence interval for the parameter _{j} may be computed from the estimate b_{j} using the computed standard deviations and the appropriate critical value t^{*} from the t(n-p-1) distribution.**

*The confidence interval for*

_{j}takes the form*b*

_{j}+ t

^{*}s

_{bj}.

*Continuing with the “Healthy Breakfast” example, suppose we choose to add the “Fiber” variable to our model. The MINITAB results are the following:*

Regression Analysis The regression equation is Rating = 53.4 - 3.48 Fat + 2.95 Fiber - 1.96 Sugars Predictor Coef StDev T P Constant 53.437 1.342 39.82 0.000 Fat -3.4802 0.6209 -5.61 0.000 Fiber 2.9503 0.2549 11.57 0.000 Sugars -1.9640 0.1420 -13.83 0.000 S = 5.235 R-Sq = 86.7% R-Sq(adj) = 86.1%

*The squared multiple correlation **R*² is now equal to 0.861, and all of the variables are significant by the *t* tests. Examination of the residuals indicates no unusual patterns. The inclusion of the “Fat,” “Fiber,” and “Sugars” variables explains 86.7% of the variability of the data, a significant improvement over the smaller models.

*For additional tests and a continuation of this example, see ANOVA for Multiple Linear Regression. *